The heavy-ion-induced desorption of organic molecules has proved effective to produce excessive yields of undamaged large organic molecules, even if they are as fragile as polypeptides, polysacharides or DNA-strings up to any mass. Contributing to elucidate the physics of this unique process is the aim of this contribution. By that we hope that on the long run theoretical model calculations of the process will help to optimize the experimental setup thus serving the wide open field of applications in biochemistry and pharmacy. In addition, learning about a complex physics phenomenon may give independent additional information to the physics of the touched fields.